Current methods of haemolysis detection and reporting as a source of risk to patient safety: a narrative review. McCaughey EJ, Vecellio E, Lake R, Li L, Burnett L, Chesher D, et al.
#Roche 5800 verification
Verification of serum indices in routine work is necessary to establish analytical specifications.Īuthor contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.Ĭompeting interests: The funding organization(s) played no role in the study design in the collection, analysis, and interpretation of data in the writing of the report or in the decision to submit the report for publication.ġ. There is heterogeneity between analyzers in the hemolysis, icteria, lipemia (HIL) quality performance. Cross reactivity analysis mostly showed that serum indices measurement is affected when a combination of interferences is present. The I index was not comparable between all analyzer combinations, while the L index was only comparable between Abbott and BC. The H index was comparable between BC and both, Architect (Cohen’s κ =0.795 ) and Roche (Cohen’s κ =0.825 ), while Roche and Architect were not comparable.
All three analyzers showed acceptable results in evaluating accuracy of L index and unacceptable results for I index. Accuracy for the H index was acceptable for Cobas and BC, while on Architect, deviations in the high concentration range were observed (y=0.02 +1.07 x). Results:īest results for precision were obtained for the H index (0.72%–2.08%). Measurements were done before and after adding interferents). The following analytical specifications were verified: precision (two patient samples), accuracy (sample with the highest concentration of interferent was serially diluted and measured values compared to theoretical values), comparability (120 patients samples) and cross reactivity (samples with increasing concentrations of interferent were divided in two aliquots and remaining interferents were added in each aliquot. This study was done on three analyzers: Abbott Architect c8000, Beckman Coulter AU5800 (BC) and Roche Cobas 6000 c501.
The aim of our study was to perform verification of serum indices on three clinical chemistry platforms.
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